B. anthracis Macrophage Invasion Mechanism

Description:

: All biology images in this gallery could be re-created using vector graphics as SVG files. This has several advantages; see Commons:Media for cleanup for more information. If an SVG form of this image is available, please upload it and afterwards replace this template with {{vector version available|new image name}}. Summary[edit] Description: English: CD14 and Mac-1 work together to increase the macrophage internalization of B. anthracis spores. (a) CD14 and TLR2 work in close proximity to propagate the activation signal. Mac-1 starts in a closed confirmation which keeps the integrin from binding the spores, keeping them out of the cell. (b) CD14 binds the rhamnose residues on the BclA of the exosporium leading to TLR2-mediated activation of PI3K. (c) Activation of PI3K pushes Mac-1 into its open conformation so the spore can be bound and internalized (information from Oliva et al. 2009). Date: 20 November 2019. Source: Own work. Author: Elizbloom.